CBD Health benefits

Do the cannabinoids have beneficial effects and can they be used as a medicine?

The two main cannabinoids with proven healing potential are THC and CBD.

There is evidence that THC can increase appetite and reduce nausea as well as affect pain, inflammation (swelling and redness) and muscle tone problems. Unlike THC, CBD is a cannabinoid that does not lead to feelings of "clogging," euphoria and addiction. It can be used to reduce pain and inflammation, to control epileptic seizures and even to treat mental illness and addictions. A large number of researchers, including those funded by the National Institute of Health (NIH), are continuing to explore the possibilities for application in the medical practice of THC, CBD and a number of other cannabinoids.

For example, recent studies have shown that marijuana extracts can help destroy some cancer cells and reduce the size of others. Cell culture studies have shown that purified marijuana extract may slow the growth of cancer cells in one of the most serious types of brain tumors. The combination of purified THC and CBD extracts with radiotherapy increases the antitumor effect of the latter.

 Currently, clinical and clinical studies with CBD are being conducted to treat various symptoms and illnesses such as:

• diseases that affect the immune system, including HIV / AIDS and multiple sclerosis (MS), which causes gradual loss of muscle control

• inflammation

• pain

• convulsions

• substance abuse

• mental disorders

How to Use CBD

CBD or more cannabidiol is one of the 104 compounds known as cannabinoids found in cannabis or marijuana plants, Cannabis sativa (1). It does not cause a state of "clogging" because it is not psychoactive. CBD oil can be used in various ways to relieve various symptoms. Products that contain CBD are available in many different forms. Some of these may be added to various foods and beverages or taken with a pipette or a dropper. Others are available in capsule form or as a thick paste that is rubbed on the skin. Some products are available as drops that are applied under the language.

Recommended doses vary between individuals and depend on factors such as body weight, product concentration and health problem.

Often, CBD oil is used to treat:

• Anxiety Anxiety

• Depression Depression

• Panic disorder

• Schizophrenia

• Chronic pain Chronic pain

• Inflammation

• Combating cancer

• Relieves nausea

• Reduces cardiovascular risk

• Reduces the risk of diabetes

• Reduces seizures

• Relieves acne

• Epilepsy

• Parkinson's disease Parkinson's disease

• Huntington's disease Huntington's disease

• Sleep disorder

• Glaucoma glaucoma glaucoma

CBD oil could improve sleep and heart health, reduce inflammation and pain, reduce oxidative stress, reduce weight loss, and protect against certain forms of cancer.

The CBD oil is obtained by extracting CBD from the cannabis plant, then diluted into carrier oil, usually coconut oil or hemp oil.

In short, the health benefits of the CBD, which are supported by scientific evidence:

1. It has an analgesic effect

Marijuana has been used to treat pain as early as 2900 BC. (2). More recently, however, scientists have found that CBD is one of its ingredients that has the pain-relieving effect. The human body has a specialized system called the Endocannabinoid System (ECS), which is involved in the regulation of various functions including sleep, appetite, pain and immune response (3). The body produces endocannabinoids, which are essentially neurotransmitters (substances that transmit information and regulate important functions) that bind to the cannabinoid receptors in the nervous system.

Studies have shown that CBD can help reduce chronic pain by affecting the activity of endocannabinoid receptors by reducing inflammation and interacting with neurotransmitters (4).

Injection of CBD reduces the painful response in a surgical incision, while oral intake greatly reduces the pain and inflammation of the sciatic nerve (5, 6).

The combination of CBD and THC is effective in treating pain associated with multiple sclerosis and rheumatoid arthritis.(7). (8).

study published in the Journal of Experimental Medicine found that CBD can significantly reduce chronic inflammation and pain. This causes researchers to assume that CBD can provide a new, more natural alternative to the treatment of chronic pain.

2. Can reduce anxiety and depression

Anxiety and depression are common psychiatric disorders that can have extremely adverse health effects. According to the World Health Organization, depression and anxiety are one of the most widespread diseases in the world (9). Drugs used for their treatment can cause many side effects, including drowsiness, agitation, insomnia, sexual dysfunction, headaches and even addiction (10). (11).

On the other hand, CBD oil could be used to treat both depression and anxiety, without being accompanied by serious side effects. (12). (13). (14, 15). It is believed that these properties are related to the ability of CBD to affect serotonin receptors in the brain - serotonin is a neurotransmitter that regulates mood and social behavior.

Can CBD really help with depression, anxiety and stress?

It is necessary to understand that there is a difference between anxiety, depression, stress. It is important to emphasize that studies are currently in progress on the role of CBD oil in the treatment of these conditions.

Stress, anxiety and depression - albeit different - have some common features.

Depression is usually triggered by a significant negative stress. Research shows that anxiety is most likely to precede depression.

Anxiety patients have an increased risk of developing depression due to stress.

In 2015, the authors of a report published in the journal Neurotherapeutics reviewed the results of experimental studies, clinical and epidemiological studies on the benefits of taking CBD butter and found evidence that it could help treat generalized anxiety disorder, panic disorder, obsessive- compulsive disorder and  traumatic stress syndrome.

Doctors often advise people with chronic anxiety to avoid cannabis use, as THC contained in THC may cause or increase feelings of anxiety and paranoia. However, PharmaHemp's CBD does not contain THC!

The authors of a review in Neurotherapeutics find that CBD can help reduce anxiety in disease states such as:

• post-traumatic stress disorder

• general anxiety disorder

• panic disorder

• Other anxiety disorder social anxiety disorder

• Obsessive-compulsive disorder 

It is noted that current treatments for these disorders often lead to serious side effects, while CBD intake is devoid of such, and therefore further study of the compound and its use in the treatment of various anxiety forms is absolutely justified.

Does the CBD affect serotonin levels?

Does the CBD oil affect serotonin levels like modern antidepressants? The cannabinoid receptor (CB1R) plays an important role in controlling behavior and mood. This receptor is present in areas such as the limbic system and the frontal regions of the cerebral cortex. It is also of great importance for serotonin transmission in the nervous system.

Can CBD worsen depression?

Studies have shown that the most common side effects after taking CBD are:

• Fatigue.

• Diarrhea.

• Changes in appetite / weight.

Compared with other drugs used to treat depression, anxiety, and stress medication, research shows CBD has a more favorable side-effect profile that CBD has a more favorable side-effect profile.

The recommendations are, however, before consulting the CBD, consult a doctor.

Which is the best CBD oil for depression Best CBD oils for depression?

The best CBD oil for depression is the quality organic CBD oil that is produced in compliance with current regulatory requirements and is subject to continuous quality and safety controls. High-quality CBD-oil manufacturers such as PharmaHemp deliver their hemp from organic farmers and carry out frequent lab tests to check for safety.

What is the recommended CBD dose for stress?

The recommended dose of CBD under stress varies from one patient to another, because everyone will respond positively to different amounts of CBD oil. CBD doses for stress studies show that CBD doses for stress response range between 1 mg / kg and 10 mg / kg.

For example, if your weight is 68 kg, the recommended starting dose of CBD at stress is approximately 68 mg.

What is the recommended dose of CBD in anxiety?
The recommended dose of anxiety varies with different situations. Each person requires a different amount of CBD oil to achieve optimal results - between 0.5 and 50 mg / kg of CBD dosing for anxiety study.

Where to buy CBD oil for depression, anxiety and stress?
It is best to buy CBD oil from a qualified and certified manufacturer who offers full-quality CBD oil with constant quality control. The effect of CBD oil is determined precisely by the interaction between the 212 phytocanabinoids (without THC) and the endocannabinoid system of the orgasm. It is this interaction that makes the CBD oil more effective at lower doses.

3. Can alleviate the symptoms associated with cancer
CBD can help reduce the symptoms associated with the oncology illness and the side effects associated with its treatment such as nausea, vomiting and pain.
Some studies even demonstrate that CBD may have anti-tumor properties, for example in breast cancer.
Some researchers claim that CBD may have cancer-causing cancer. According to a review of the British Journal of Clinical Pharmacology, the CBD significantly inhibits the spread of cancer cells. It is also noted that CBD has the ability to inhibit the growth of cancer cells as well as to facilitate their destruction. Since the CBD is not related to the occurrence of serious toxic effects, the authors of the article recommend a deeper study of the CBD and its use as a complement to standard anti-tumor therapy.

4. Can reduce acne
Acne is a common condition affecting more than 9% of the population.
Its causes are complex and include genetic factors, bacteria, inflammation and overproduction of sebum by the sebaceous glands in the skin.
CBD oil can have a beneficial effect on acne because of its anti-inflammatory properties and its ability to control over-production of sebum by the sebaceous glands.
Acne Acne is caused, or at least in part, by inflammation and overproducing sebaceous glands in the body. A study in 2014, published in the Journal of Clinical Investigation, found that CBD helps reduce sebum production, leading to acne, partly due to its generalized anti-inflammatory action. Sebum is an oily substance whose overproduction can in itself cause acne. That is why CBD products can become the future treatment of acne vulgaris, the most common form of acne.

5. May have neuroprotective properties
The ability of CBD to interact with endocannabinoid and other brain signaling systems can have a positive effect in patients with neurological disorders such as epilepsy and multiple sclerosis.
Several studies have shown that CBD intake improves quality of life and sleep quality in people suffering from Parkinson's disease as well as reduce inflammation, prevent cognitive impairment and neurodegeneration associated with Alzheimer's disease.
According to the research published in the Journal of Alzheimer's Disease research, CBD is able to prevent the development of a cognitive deficit. This means that the CBD can help patients in early stages of Alzheimer's disease retain their ability to recognize the faces of the people they know. This is also the first evidence that CBD may slow the progression of Alzheimer's disease.
Following a study of the safety and efficacy of CBD oil in the treatment of epilepsy, in 2018, the FDA approved the use of CBD (Epidiolex) as a therapy in two rare conditions characterized by epileptic seizures:
• Lennox-Gastaut syndrome (LGS) - a condition that occurs between 3 and 5 years of age and involves different types of seizures;
• Dravet syndrome (DS) - a rare genetic disorder that occurs during the first year of life and involves frequent convulsions and fever.
The effects of CBD have also been studied in various neuropsychiatric disorders. In a review review in 2014, it is noted that CBD has anti-epileptic properties and a low risk of side effects in people with epilepsy. Evidence suggests that CBD can treat many of the complications associated with epilepsy, such as neurodegenerative changes, neuronal damage, and mental illness.  Another study, published in Current Pharmaceutical Design, found that CBD can cause effects similar to those with some antipsychotic drugs, and that the compound can provide safe and effective treatment for people with schizophrenia. However, additional studies are needed to conclusively confirm the benefit of the use of the product in these conditions.

6. It can improve the function of the cardiovascular system.
High blood pressure is associated with a risk for a number of disease states, including stroke, heart attack and metabolic syndrome (33).
Studies have shown that CBD can be a natural and effective treatment for high blood pressure. (34).
In addition, CBD can help reduce inflammation and cell death associated with heart disease due to its powerful antioxidant properties. (35).
In a study published in JCI Insight magazine in 2017, researchers note that CBD can help prevent stress-related changes in blood pressure. According to the study, patients who received CBD oil had lower blood pressure both before and after experiencing a stressful event.

7. Other potential benefits of using CBD
• Antipsychotic effects: Studies have shown that CBD oil can help people with schizophrenia and other mental disorders by reducing psychotic symptoms  (36).
• Treatment of drug addictions: CBD has been shown to influence the brain processes responsible for addiction - reducing morphine and cocaine dependence. (37).
A review article published in the Substance Abuse magazine in 2015 states that CBD oil may be beneficial in patients who are addicted. In their analysis of existing evidence, researchers have found that CBD can have a therapeutic effect in people with opiate, cocaine and / or other psychostimulant dependence, including in the treatment of cannabis and tobacco dependence. Evidence suggests that CBD can block or reduce the effects of THC on the human brain.
• Antitumor effects: CBD shows anti-tumor effects by preventing the spread of breast, prostate, brain, colon and lung cancer (38).
• Prevention of diabetes: CBD treatment reduces the incidence of diabetes by 56% and significantly reduces inflammation (39)Type diabetes is a result of inflammation that occurs when the immune system attacks pancreatic cells. Data published in 2016 in Clinical Hemorheology and Microcirculation Researchdemonstrate that CBD can alleviate pancreatic inflammation. This may be the first step in finding treatment for type I diabetes patients. The evidence presented in that year suggests that the CBD may reduce may reduce inflammation and protect against or delay the development of type I diabetes.
• Stopping smoking and drug use: Using CBD can help people quit smoking. A pilot study published in Addictive Behaviors found that smokers who use CBD inhalers smoke fewer cigarettes and have a lower nicotine dependence. Another review, review published in Neurotherapeutics shows that CBD has the potential to be used as a treatment in people suffering from addiction. It is noted that CBD reduces some of the withdrawal symptoms associated with stopping the use of addictive substances such as anxiety, mood swings, pain and insomnia. More research is needed to confirm these findings.

Is cannabis safe?
Overall, CBD is well tolerated by adult patients. So far, no serious central nervous system, vitality (pulse, blood pressure, pacemaker, respiratory rate) or mood has been found to be serious, even among people who used high doses of CBD.
Side effects of CBD are extremely rare adverse effects. As such, signs of nausea, fatigue, tiredness, irritability, and appetite changes may be noted. (40).
Some studies have shown that the use of high-dose CBD oil can cause side effects such as anxiety, changes in appetite, mood swings, diarrhea, dizziness, drowsiness, dry mouth, nausea. It should also be noted that the use of CBD oil can increase liver enzymes. CBD may raise the blood levels of some drugs by the same mechanism as after grapefruit juice. The main danger of taking the substance is that it is sold primarily as an additive and not as a medicine, therefore its purity and quality is not always at the highest level and it is not always known whether the product contains other unknown ingredients . The most effective therapeutic doses of CBD for any particular medical condition are not yet known, so it is always advisable to consult a doctor before taking the CBD.
A report from the American Pediatrics Academy (AAP) published in Pediatrics magazine warns that pregnant women and breastfeeding mothers should avoid marijuana use due to possible adverse effects on their baby - short-term intake of CBD increases the placental membrane permeability, which potentially could increase the risk to the fetus when taking other substances.
Therefore, if you are considering taking CBD butter, it is advisable to discuss the potential side effects and side effects with your doctor.
CBD oils of some manufacturers may contain THC. Cannabis, which also contains THC, can impair your ability to drive and work safely, as well as having short-term and long-term effects on memory, attention, mood, heart rate and mental health.
When using CBD oil, it is important to start with a low dose, gradually increasing it. Depending on your condition, it may take up to several hours for you to feel the effects after consuming CBD oil.

Evidence of the benefits of cannabidiol
CBD has a wide range of health problems but the strongest scientific evidence is its effectiveness in the treatment of some of the worst forms of childhood epilepsy, such as Dravet's syndrome and Lennox-Gastaut syndrome (LGS), which are usually difficult to manage with portillo-epileptic drugs. Studies have shown that CBD reduces the number of seizures and in some cases is able to stop them completely. That's what led the FDA to approve the first drug derived from cannabis and containing CBD ffirst ever cannabis-derived medicine that can be used to treat these diseases - Epidiolex.
CBD is commonly used to deal with anxiety, and in patients who suffer from insomnia, studies show that CBD can help both the sleep process and the duration of sleep.
CBD can be offered as an option for the treatment of various types of chronic pain. A study from the European Journal of Pain shows that applied to the skin CBD can reduce arthritis-related pain and inflammation. Another study demonstrates the mechanisms by which CBD suppresses inflammatory and neuropathic pain - two of the most difficult to treat types of chronic pain. Of course, further studies in this area are needed to further prove the effect of CBD in the various pain-related conditions.

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The CBD is already very popular with athletes after a number of professional athletes confirm that the CBD accelerates recovery time after training.
For the same reason, CBD oil is popular with MMA contestants.